Sitting all day and where the seams sit
Short answer: Choose underwear with flat seams and no seam down the centre back. If you sit for many hours, that is the detail you feel most.
Where the pressure falls when sitting
Weight rests on the sitting bones and the backs of the thighs. A thick seam or an edge lying exactly there creates a pressure that grows clearer by the hour. That is why seam position matters more than the fabric.
What to look for
Underwear with no centre back seam, or with a flat stitched seam, is the best choice. A wide, soft leg edge rather than a narrow elastic also makes a difference. See bamboo underwear briefs for men.
The trousers count too
Trousers with a back seam in thick fabric or with rivets can press through the underwear. Soft fabric without hard details on the back is easiest. See bamboo trousers for women and bamboo underwear for women.
Frequently asked questions
Do seamless styles help
Yes, noticeably. They have no edges that can press.
What about changing position
That remains the most important thing. Stand up regularly whatever you are wearing.
What if the skin becomes red
Change to softer clothing and change position more often. With persistent redness, contact your doctor.